• Users Online: 504
  • Print this page
  • Email this page
Year : 2019  |  Volume : 7  |  Issue : 1  |  Page : 1-8

Potential toxic effect of bisphenol A on the cardiac muscle of adult rat and the possible protective effect of Omega-3: A histological and immunohistochemical study

1 Department of Histology and Cell Biology, Faculty of Medicine, Tanta University, Egypt
2 Department of Histology, Faculty of Medicine, Sohag University, Egypt
3 Department of Pharmacology, Faculty of Medicine, Tanta University, Egypt; Center for Discovery Brain Science, Edinburgh University, United Kingdom

Correspondence Address:
Dr. Noha Gamal Bahey
Department of Histology and Cell Biology, Faculty of Medicine, Tanta University, Tanta 31527
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/JMAU.JMAU_53_18

Get Permissions

Bisphenol A (BPA) is intensely used in the production of polycarbonate plastics and epoxy resins. Recently, BPA has been receiving increased attention due to its link to various health problems that develop after direct or indirect human exposure. Previous studies have shown the harmful effect of high doses of BPA; however, the effect of small doses of BPA on disease development is controversial. The aim of this study was to investigate the effect of a low dose of BPA on the rat myocardium and to explore the outcome of coadministration of Omega-3 fatty acid (FA). Thirty adult male rats were divided equally into control group, BPA-treated group (1.2 mg/kg/day, intraperitoneally for 3 weeks), and BPA and Omega-3-treated group (received BPA as before plus Omega-3 at a daily dose of 300 mg/kg/day orally) for 3 weeks. Exposure to BPA resulted in structural anomalies in the rat myocardium in the form of disarrangement of myofibers, hypertrophy of myocytes, myocardial fibrosis, and dilatation of intramyocardial arterioles. On the other hand, mast cell density and media-to-lumen area ratio were not significantly altered. Interestingly, concomitant administration of Omega-3 FAs with BPA significantly reduced BPA-induced changes and provided a protective effect to the myocardium. In conclusion, exposure to a low dose of BPA could potentially lead to pathological alterations in the myocardium, which could be prevented by administration of Omega-3 FA.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded279    
    Comments [Add]    
    Cited by others 3    

Recommend this journal