| CASE REPORT |
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| Year : 2019 | Volume
: 7
| Issue : 4 | Page : 198-200 |
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Increased copy number of anaplastic lymphoma kinase gene signal in lung carcinomas: Is it significant?
Saumya Shukla1, Nuzhat Husain1, Kiran Preet Malhotra1, Vandana Tiwari2
1 Department of Pathology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
2 Department of Biochemistry, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
Correspondence Address:
Dr. Saumya Shukla
Department of Pathology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow - 226 010, Uttar Pradesh
India
 Source of Support: None, Conflict of Interest: None
DOI: 10.4103/JMAU.JMAU_9_19
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The anaplastic lymphoma kinase gene re-arrangement which is present in 3-5% cases of non small cell lung cancer is a somatic gene re-arrangement. The gold standard for the identification of this gene re-arrangement is fluorescence in situ hybridization. Many variant hybridization patterns have been documented. We present a case of polysomy of ALK gene in the absence of ALK gene re-arrangement in a 45 year old female who presented with brain metastasis. This is a rare case of polysomy of ALK gene reported in a non small cell lung carcinoma. It may be indicative of a worse prognosis and may predict high metastatic potential in these tumors.
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