Journal of Microscopy and Ultrastructure

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 7  |  Issue : 1  |  Page : 19--27

Immunohistochemical expression of E- and N-Cadherin in nodular prostatic hyperplasia and prostatic carcinoma


Rania Abdallah Abdallah, Asmaa Gaber Abdou, Moshira Abdelwahed, Hend Ali 
 Department of Pathology, Faculty of Medicine, Menoufia University, Shebein El Kom, Egypt

Correspondence Address:
Dr. Asmaa Gaber Abdou
Department of Pathology, Faculty of Medicine, Menofia University, Shebein El Kom
Egypt

Background: Different theories have been postulated to explain the development of nodular prostatic hyperplasia (NPH). Epithelial to mesenchymal transition (EMT) is a physiologic process in which the epithelial cells lose their polarity and cell-cell adhesion and acquire a mesenchymal phenotype. Aim: The aim of the present study is to investigate the potential role of E- and N-cadherin in the induction of EMT in NPH and prostatic carcinoma. Methods: This study was carried out on 55 cases of NPH and 20 cases prostatic carcinoma for evaluation of immunohistochemical expression of E and N cadherins. Results: Most NPH (54/55 cases, 98.2%) and all cases of prostatic carcinoma showed positive N-cadherin expression in prostatic glands and stroma. High percentage of N-cadherin expression by stromal cells was significantly in favor of prostatic carcinoma compared to NPH. High percentage of N-cadherin expression by epithelial cells of carcinoma group was significantly associated with young age while its high expression by stromal cells was significantly associated with multicentricity. About 96.4% of NPH and 75% of prostatic carcinoma showed positive E-cadherin expression with a significant difference. No significant association between E-cadherin and N-cadherins in both NPH and prostatic carcinoma was identified. Conclusions: The prominent expression of N-cadherin in large numbers of NPH and prostate carcinoma cases in the epithelial and stromal components could point to the occurrence of EMT in those diseases. It also opens a new gate for treatment of those patients by targeting N-cadherin molecule. The absence of inverse association between E-cadherin and N-cadherins in NPH and prostatic carcinoma may indicate that cadherin switch is not an essential step for the development of EMT.


How to cite this article:
Abdallah RA, Abdou AG, Abdelwahed M, Ali H. Immunohistochemical expression of E- and N-Cadherin in nodular prostatic hyperplasia and prostatic carcinoma.J Microsc Ultrastruct 2019;7:19-27


How to cite this URL:
Abdallah RA, Abdou AG, Abdelwahed M, Ali H. Immunohistochemical expression of E- and N-Cadherin in nodular prostatic hyperplasia and prostatic carcinoma. J Microsc Ultrastruct [serial online] 2019 [cited 2020 Jul 11 ];7:19-27
Available from: http://www.jmau.org/article.asp?issn=2213-879X;year=2019;volume=7;issue=1;spage=19;epage=27;aulast=Abdallah;type=0