Journal of Microscopy and Ultrastructure

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 7  |  Issue : 1  |  Page : 1--8

Potential toxic effect of bisphenol A on the cardiac muscle of adult rat and the possible protective effect of Omega-3: A histological and immunohistochemical study


Noha Gamal Bahey1, Hekmat Osman Abd Elaziz2, Kamal Kamal Elsayed Gadalla3 
1 Department of Histology and Cell Biology, Faculty of Medicine, Tanta University, Egypt
2 Department of Histology, Faculty of Medicine, Sohag University, Egypt
3 Department of Pharmacology, Faculty of Medicine, Tanta University, Egypt; Center for Discovery Brain Science, Edinburgh University, United Kingdom

Correspondence Address:
Dr. Noha Gamal Bahey
Department of Histology and Cell Biology, Faculty of Medicine, Tanta University, Tanta 31527
Egypt

Bisphenol A (BPA) is intensely used in the production of polycarbonate plastics and epoxy resins. Recently, BPA has been receiving increased attention due to its link to various health problems that develop after direct or indirect human exposure. Previous studies have shown the harmful effect of high doses of BPA; however, the effect of small doses of BPA on disease development is controversial. The aim of this study was to investigate the effect of a low dose of BPA on the rat myocardium and to explore the outcome of coadministration of Omega-3 fatty acid (FA). Thirty adult male rats were divided equally into control group, BPA-treated group (1.2 mg/kg/day, intraperitoneally for 3 weeks), and BPA and Omega-3-treated group (received BPA as before plus Omega-3 at a daily dose of 300 mg/kg/day orally) for 3 weeks. Exposure to BPA resulted in structural anomalies in the rat myocardium in the form of disarrangement of myofibers, hypertrophy of myocytes, myocardial fibrosis, and dilatation of intramyocardial arterioles. On the other hand, mast cell density and media-to-lumen area ratio were not significantly altered. Interestingly, concomitant administration of Omega-3 FAs with BPA significantly reduced BPA-induced changes and provided a protective effect to the myocardium. In conclusion, exposure to a low dose of BPA could potentially lead to pathological alterations in the myocardium, which could be prevented by administration of Omega-3 FA.


How to cite this article:
Bahey NG, Abd Elaziz HO, Elsayed Gadalla KK. Potential toxic effect of bisphenol A on the cardiac muscle of adult rat and the possible protective effect of Omega-3: A histological and immunohistochemical study.J Microsc Ultrastruct 2019;7:1-8


How to cite this URL:
Bahey NG, Abd Elaziz HO, Elsayed Gadalla KK. Potential toxic effect of bisphenol A on the cardiac muscle of adult rat and the possible protective effect of Omega-3: A histological and immunohistochemical study. J Microsc Ultrastruct [serial online] 2019 [cited 2020 Jul 11 ];7:1-8
Available from: http://www.jmau.org/article.asp?issn=2213-879X;year=2019;volume=7;issue=1;spage=1;epage=8;aulast=Bahey;type=0