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  Indian J Med Microbiol
 

Figure 3: Electron micrographs of ultrathin sections of rat sciatic nerve of Aspartame Group showing (A) separation (incisures) of myelin lamellae (arrow) with (B) focal loss of compact lamellar structure (splitting) of myelin sheath (double arrow), (C) discontinuous and disorganized myelin sheath (biffed arrow) with (D) marked lysis (star), (E, F) abnormal and irregular thickening of myelin (waved arrow), with compressed distorted axoplasm (Ax), (G, H) Schwann cells (Sch) with swollen and destroyed mitochondria (M), dilated rough endoplasmic reticulum (R), and vacuolation (V) of the cytoplasm.

Figure 3: Electron micrographs of ultrathin sections of rat sciatic nerve of Aspartame Group showing (A) separation (incisures) of myelin lamellae (arrow) with (B) focal loss of compact lamellar structure (splitting) of myelin sheath (double arrow), (C) discontinuous and disorganized myelin sheath (biffed arrow) with (D) marked lysis (star), (E, F) abnormal and irregular thickening of myelin (waved arrow), with compressed distorted axoplasm (Ax), (G, H) Schwann cells (Sch) with swollen and destroyed mitochondria (M), dilated rough endoplasmic reticulum (R), and vacuolation (V) of the cytoplasm.