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  Indian J Med Microbiol
 

Figure 1: Photomicrographs of the rat spleen. (a) A control one showing the parenchyma with aggregation of lymphocytes around the arteriole (A) in the white pulp, marginal zone (M) around it and the different cell series in the red pulp (R). (b). a rat spleen from the CsA group, showing marked decrease in the lymphocytes in the periarteriolar area of the white pulp (w). Notice the marked increase in dilated sinusoids with difficult demarcation between different zones. (c) A rat spleen from CsA + Echinacea purpurea root (100 mg/kg BW) group, showing the active germinal center (GC) of the white pulp with predominance of the cell nest appearance of the macrophages (⟶) and increased number of large macrophages (▸) in the marginal zone (M). (d) a rat spleen from CsA + Echinacea purpurea root (200 mg/kg BW) group, showing the increased number of activated lymphocytes in the marginal zone (M). Arteriole (A) and white pulp (W). Bar 50 μ (H and E stain)

Figure 1: Photomicrographs of the rat spleen. (a) A control one showing the parenchyma with aggregation of lymphocytes around the arteriole (A) in the white pulp, marginal zone (M) around it and the different cell series in the red pulp (R). (b). a rat spleen from the CsA group, showing marked decrease in the lymphocytes in the periarteriolar area of the white pulp (w). Notice the marked increase in dilated sinusoids with difficult demarcation between different zones. (c) A rat spleen from CsA + <i>Echinacea purpurea</i> root (100 mg/kg BW) group, showing the active germinal center (GC) of the white pulp with predominance of the cell nest appearance of the macrophages (⟶) and increased number of large macrophages (▸) in the marginal zone (M). (d) a rat spleen from CsA + <i>Echinacea purpurea</i> root (200 mg/kg BW) group, showing the increased number of activated lymphocytes in the marginal zone (M). Arteriole (A) and white pulp (W). Bar 50 μ (H and E stain)