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  Indian J Med Microbiol
 

Figure 3: Photomicrographs of rat liver. Group 1: Control showing normal hepatocytes (H) near central vein (CV) and portal area (PA). Blood sinusoids (S) are of normal appearance and showed endothelial and Kupffer (K) cells. Portal vein (PV), bile duct (BD), and hepatic artery (HA) surrounded by scanty connective tissue with few mononuclear cells and fibroblasts (stars). Group 2: PPE showing no alteration in normal structure of hepatic tissue. Hepatocytes (H) showed active vesicular nuclei (arrows). Slight dilation of blood sinusoids(s) could be observed. Portal area showed normal triad (PV, HA, and BD). Group 3: STZ diabetes: Focal hepatocyte necrosis (black star) is seen around the central vein (CV) which showed dilation and damage of its lining epithelium (black arrows). Sporadic (apoptotic) cells with dark stained acidophilic cytoplasm and small dark (pyknotic) nuclei (white arrows). Portal area showed dilated numerous bile ducts (BD) portal vein dilation (PV) surrounded by inflammatory cells (stars). Group 4: PPE before STZ diabetes: showing marked protection against diabetic induced changes. Hepatocytes looked normal with rounded central vesicular active nuclei (dotted arrows). Blood sinusoids (S) are normal and showing prominent Kupffer cells (K, black arrows). Portal area showed normal bile duct (BD), hepatic artery (HA). Connective tissue around them showed few inflammatory cells (white star) (H and E). STZ: Streptozotocin

Figure 3: Photomicrographs of rat liver. Group 1: Control showing normal hepatocytes (H) near central vein (CV) and portal area (PA). Blood sinusoids (S) are of normal appearance and showed endothelial and Kupffer (K) cells. Portal vein (PV), bile duct (BD), and hepatic artery (HA) surrounded by scanty connective tissue with few mononuclear cells and fibroblasts (stars). Group 2: PPE showing no alteration in normal structure of hepatic tissue. Hepatocytes (H) showed active vesicular nuclei (arrows). Slight dilation of blood sinusoids(s) could be observed. Portal area showed normal triad (PV, HA, and BD). Group 3: STZ diabetes: Focal hepatocyte necrosis (black star) is seen around the central vein (CV) which showed dilation and damage of its lining epithelium (black arrows). Sporadic (apoptotic) cells with dark stained acidophilic cytoplasm and small dark (pyknotic) nuclei (white arrows). Portal area showed dilated numerous bile ducts (BD) portal vein dilation (PV) surrounded by inflammatory cells (stars). Group 4: PPE before STZ diabetes: showing marked protection against diabetic induced changes. Hepatocytes looked normal with rounded central vesicular active nuclei (dotted arrows). Blood sinusoids (S) are normal and showing prominent Kupffer cells (K, black arrows). Portal area showed normal bile duct (BD), hepatic artery (HA). Connective tissue around them showed few inflammatory cells (white star) (H and E). STZ: Streptozotocin