Journal of Microscopy and Ultrastructure

ORIGINAL ARTICLE
Year
: 2015  |  Volume : 3  |  Issue : 1  |  Page : 19--24

Bcl-2 may play a role in the progression of endometrial hyperplasia and early carcinogenesis, but not linked to further tumorigenesis


Mohamed Laban1, Eman Abdel-Salam Ibrahim2, Wael Agur3, Ahmed M Bahaaa Elddin Ahmed1 
1 Department of Obstetrics & Gynecology, Faculty of Medicine, Ain Shams University, Cairo, Egypt
2 Department of Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt
3 Department of Obstetrics & Gynecology, Faculty of Medicine, Ain Shams University, Cairo, Egypt; Department of Obstetrics & Gynecology, NHS Ayrshire & Arran, NHS Research Scotland, UK

Correspondence Address:
Mohamed Laban
Department of Obstetrics & Gynecology, Faculty of Medicine, Ain Shams University, Al-Abbasiya-Square, Cairo
Egypt

The role of Bcl-2 in initiation and progression of endometrial carcinoma is still with inconsistent results. The aim of this study is to determine the role of Bcl-2 in endometrial tumorigenesis. It is a retrospective cross sectional study. We used 100 endometrial paraffin embedded specimens for Bcl-2 oncoprotein immunohistochemical staining; 20 samples of normal endometrium, 40 specimens of endometrial hyperplasia (simple, complex and atypical) and 40 specimens of endometrioid adenocarcinoma. The results were statistically analyzed. There was a significant increase in Bcl-2 staining from normal through complex and atypical hyperplasia into well differentiated adenocarcinoma (P =0.002, P =0.0008 and P =0.0001, respectively). There was a significant difference between the staining of different types of endometrial hyperplasia; as it up streamed from the simple through the complex up to the atypical types (P <0.05). Bcl-2 staining showed no significant correlation with the moderately, poorly differentiated and the different stages of adenocarcinoma (P =0.6, P =0.29 and P =0.1 respectively). These results might indicate a substantial role for Bcl-2 as one of the initiating drives for endometrial tumorigenesis, but not in further tumor progression.


How to cite this article:
Laban M, Ibrahim EA, Agur W, Bahaaa Elddin Ahmed AM. Bcl-2 may play a role in the progression of endometrial hyperplasia and early carcinogenesis, but not linked to further tumorigenesis.J Microsc Ultrastruct 2015;3:19-24


How to cite this URL:
Laban M, Ibrahim EA, Agur W, Bahaaa Elddin Ahmed AM. Bcl-2 may play a role in the progression of endometrial hyperplasia and early carcinogenesis, but not linked to further tumorigenesis. J Microsc Ultrastruct [serial online] 2015 [cited 2021 Apr 15 ];3:19-24
Available from: https://www.jmau.org/article.asp?issn=2213-879X;year=2015;volume=3;issue=1;spage=19;epage=24;aulast=Laban;type=0