Journal of Microscopy and Ultrastructure

REVIEW ARTICLE
Year
: 2020  |  Volume : 8  |  Issue : 4  |  Page : 141--145

COVID-19 and phosphodiesterase enzyme type 5 inhibitors


Hayder M Al-Kuraishy1, Ali I Al-Gareeb1, Marwa S Al-Niemi2, Ali K Al-Buhadily1, Nasser A Al-Harchan3, Claire Lugnier4 
1 Department of Clinical Pharmacology, Medicine and Therapeutic, Medical Faculty, College of Medicine, Al-Mustansiriyia University, Baghdad, Iraq
2 Department of Clinical Pharmacology, Medicine and Therapeutic, Medical Faculty, College of Medicine, Al-Farahedi University, Baghdad, Iraq
3 Department of Clinical Pharmacology, College of Dentistry, Al-Rasheed University, Baghdad, Iraq
4 Department EA 3072 “Mitochondria, Oxidative Stress and Muscular Protection”, Institute of Physiology, Faculty of Medicine, Strasbourg Cedex, France

Correspondence Address:
Prof. Hayder M Al-Kuraishy
Department of Clinical Pharmacology, Medicine and Therapeutic, Medical Faculty College of Medicine, Al-Mustansiriya University, P O Box 14132, Baghdad
Iraq

COVID-19 pathology is mainly associated to a pulmonary disease which sometimes might result in an uncontrollable storm related to inflammatory diseases which could be fatal. It is well known that phosphodiesterase enzyme type 5 inhibitors (PDE5Is), such as sildenafil, have been successfully developed for the treatment of pulmonary arterial hypertension; interestingly, more recently, it was shown that PDE5Is might be also anti-inflammatory. Therefore, it would be of interest to question about the use of PDE5Is to overcome the COVID-19 storm, as much as PDE5 is mainly present in the lung tissues and vessels.


How to cite this article:
Al-Kuraishy HM, Al-Gareeb AI, Al-Niemi MS, Al-Buhadily AK, Al-Harchan NA, Lugnier C. COVID-19 and phosphodiesterase enzyme type 5 inhibitors.J Microsc Ultrastruct 2020;8:141-145


How to cite this URL:
Al-Kuraishy HM, Al-Gareeb AI, Al-Niemi MS, Al-Buhadily AK, Al-Harchan NA, Lugnier C. COVID-19 and phosphodiesterase enzyme type 5 inhibitors. J Microsc Ultrastruct [serial online] 2020 [cited 2021 Jan 20 ];8:141-145
Available from: https://www.jmau.org/article.asp?issn=2213-879X;year=2020;volume=8;issue=4;spage=141;epage=145;aulast=Al-Kuraishy;type=0